
Semax
A neuroprotective peptide that enhances cognition and dopamine activity.
Quickstart Highlights
Semax 10mg dosage protocol is commonly used to support cognitive function, neuroprotection, and potential stroke recovery through subcutaneous injections.
Typical starting dose between 300-600 mcg per day
Flexible injection frequency; daily or every-other-day subcutaneous use is common
Higher “advanced” doses up to 900 mcg daily observed in post-stroke protocols (split into 2-3 doses)
Reconstitute to a practical concentration for accurate dosing
Storage: Lyophilized: store at room temperature in a dark spot or in its box; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F). Avoid repeated freeze–thaw cycles.
Dosing & Reconstitution Guide
Standard / Gradual Approach (3 mL = 3.33 mg/mL)
Weeks | Daily Dosage (mg) | Units (per injection) |
|---|---|---|
Weeks 1–4 | 0.3 mg once daily | ~9 units |
Weeks 5–8 | 0.6 mg once daily | ~18 units |
This approach is popular for general cognitive support or mild neuroprotection. Reconstitute with 3 mL of bacteriostatic water to create a solution of about 3.33 mg/mL (≈33 mcg per unit).
Draw 3.0 mL of bacteriostatic water with a sterile syringe.
Inject the water slowly into the vial, aiming against the vial wall to avoid foaming.
Gently swirl or roll the vial until the powder fully dissolves (do not shake vigorously).
Refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Advanced Approach (2mL = 5 mg/mL)
Days | Daily Dosage (mg) | Units (per injection) |
|---|---|---|
Days 1–10 | 0.3 mg - two to three times daily | 6 units |
This higher-dose protocol is sometimes referenced in post-stroke settings. Reconstitute with 2 mL to create a 5 mg/mL solution (≈50 mcg per unit).
Draw 2.0 mL of bacteriostatic water with a sterile syringe.
Inject the water slowly into the vial, aiming against the vial wall to avoid foaming.
Gently swirl or roll the vial until the powder fully dissolves (do not shake vigorously).
Refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Supplies Needed
Plan based on an 8 week daily protocol with gradual titration.
Peptide Vials:
• 4 wks ≈ 1 vial (standard daily use)
• 8 wks ≈ 2 vialsInsulin Syringes:
• 4 wks ≈ 28 syringes (if daily)
• 8 wks ≈ 56 syringes (if daily)Bacteriostatic Water (1*10 mL bottle): Use ~3.0 mL per vial for reconstitution.
Alcohol Swabs: One for vial stopper + one for skin per injection.
Per week: 14 swabs
8 weeks: 112 swabs total
Protocol Overview
Concise summary of the once‑daily regimen.
Goal: Enhance cognitive function, neuroprotection, or aid stroke recovery
Schedule: Daily or every-other-day subcutaneous injections
Dose Range: 300-600 mcg per day
Reconstitution: Use ~3 mL for ease of measuring (~3.33 mg/mL)
Storage: Lyophilized vials frozen; reconstituted solution refrigerated; avoid refreezing.
Dosing Protocol
Suggested daily or every other day injection approach for effective titration.
Daily Dose: Start at 300 mcg per day; increase gradually as tolerated
Frequency: Daily or every-other-day, subcutaneous
Cycle Length: 4–8 weeks for general use; shorter, more intense cycles for stroke
Maximum Dose: Up to ~500 mcg daily, based on personal response
Timing: Morning injections are common;
‼️ Important Notes
Practical considerations for consistency and safety.
Use a new sterile insulin syringe for each injection and dispose of needles in a proper sharps container.
Rotate injection sites (abdomen, thigh, upper arm) to minimize local irritation or tissue changes over time.
Inject slowly and steadily; after injection, wait a few seconds before withdrawing the needle to prevent leakage.
Track progress throughout the protocol, adjusting dosage as recommended.
General subcutaneous injection guidance (for educational purposes).
Clean the vial’s rubber stopper and your chosen injection site with alcohol swabs; let them air-dry.
Using an insulin syringe, pinch a fold of skin and insert the needle at a 45–90° angle into the subcutaneous tissue (fat layer).
Do not aspirate (no need to pull back on the plunger) for subcutaneous injections. Inject the peptide slowly and steadily.
After injection, dispose of the syringe safely. Rotate injection sites (abdomen, thighs, upper arms) to prevent irritation or scar tissue build-up.
Potential Benefits & Side Effects
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH), known for its neurotropic and neuroprotective properties.
Neurological Support: May elevate brain-derived neurotrophic factor (BDNF) levels
Cognitive Enhancement: Frequently used to improve focus and mental clarity
Promotes neuronal plasticity and may aid in recovery from certain neurological injuries
Most users report improved cognition, though individual responses vary.
May support enhanced memory retention and learning
Neuroprotective effects could aid in stroke recovery protocols
Possible mild side effects include headache, restlessness, or slight blood pressure fluctuations
Rarely, injection-site irritation or allergic reactions could occur
Important Note
This content is intended for educational purposes only and is not medical advice, diagnosis, or treatment.
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