SELANK

The Calm & Collected Peptide | Synthetic Tuftsin Analog - Anxiolytic & Nootropic Peptide

What is Selank?

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. This anxiolytic and nootropic peptide has been extensively studied for its ability to reduce anxiety, enhance cognitive function, and modulate immune responses without the side effects associated with traditional benzodiazepines. Selank works through complex interactions with GABAergic, serotonergic, and dopaminergic neurotransmitter systems, offering a unique mechanism for stress reduction and cognitive enhancement.

The Calm & Collected Peptide Selank is a "nootropic" (brain-enhancing) peptide that provides a sense of calm and stability without making you feel sleepy or "drugged." It works by balancing the chemicals in your brain that manage stress and anxiety, making it easier to handle a busy life.

Key Benefits

Rapid onset anxiolytic effects, enhanced BDNF expression, improved stress resilience, cognitive enhancement, immune modulation, no tolerance or withdrawal, neuroprotective effects.

Anxiety Relief: Calms the nervous system without the side effects of traditional anti-anxiety meds.
Stress Management: Helps you stay cool and productive during high-pressure situations.
Improved Mood: Promotes a steady, positive emotional state.
Mental Sharpness: Unlike many sedatives, it actually helps you think more clearly while relaxed.
Immune Balance: Helps the immune system stay strong during times of high stress.
Social Comfort: Can help reduce social anxiety and improve communication flow.

Quick Start Guide

Typical Dose

250-500mcg per injection

How Often

Once daily morning, or split twice daily

Where to Inject

Subcutaneous: abdomen, thigh, or upper arm

Injection Timing

Morning for cognitive benefits, evening for anxiety

Effects Timeline

Anxiety relief 30-60 min, cognitive effects 1-3 days, peak benefits 1-2 weeks

Storage

Refrigerate at 2-8°C, use within 30 days of reconstitution

Cycle Length

2-8 weeks, break not required but recommended

Break Between

1-2 weeks between cycles (optional)

Research Indications

🟢 Anxiety - Most Effective

Generalized Anxiety Disorder

Clinical trials demonstrate significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation, amnesia, or dependence potential

Post-Traumatic Stress Disorder

Emerging research shows effectiveness in PTSD treatment, helping stabilize stress responses and emotional regulation without cognitive impairment

Social Anxiety and Performance Stress

Reduces anticipatory anxiety and social stress while maintaining cognitive clarity and emotional stability during challenging situations

🔵 Cognitive - Effective

Memory and Learning Enhancement

Improves memory consolidation and learning processes, particularly effective in subjects with initially poor cognitive performance

Attention and Focus Improvement

Enhances concentration and mental clarity without stimulant effects, beneficial for ADHD-like symptoms and cognitive fatigue

Neuroprotective Effects

Increases BDNF expression supporting neuroplasticity, potentially protective against age-related cognitive decline and neurodegenerative processes

⚪️ Immunity - Moderate

Immune System Modulation

Balances T-helper cell cytokines and modulates IL-6 expression, supporting healthy immune responses without over-activation

Antiviral Activity

Demonstrated effectiveness against multiple viruses including influenza, herpes simplex, and cytomegalovirus through immune enhancement

Inflammation Regulation

Modulates inflammatory gene expression and reduces chronic inflammation markers while supporting appropriate immune responses

What to expect

Mild anxiety reduction within 30-60 minutes of injection
Improved mental clarity and focus within 1-3 days
Enhanced stress resilience and emotional stability by week 1
Better sleep quality and reduced nervous tension
Cognitive enhancement effects peak around 1-2 weeks
No sedation, drowsiness, or cognitive impairment
Potential mild injection site irritation initially
Sustained benefits may last several days after discontinuation

Side Effects & Safety

Side Effects	When to Stop
Start with lowest effective dose (250mcg) to assess individual response Selank has excellent safety profile with minimal reported side effects No known tolerance, dependence, or withdrawal issues reported Can be safely combined with most medications under medical supervision Store properly refrigerated to maintain peptide stability and potency Use sterile injection techniques to prevent infection Consult healthcare provider if taking multiple psychiatric medications	Severe allergic reactions (rash, difficulty breathing, swelling) Persistent injection site reactions or signs of infection Unusual mood changes or increased anxiety (rare) Severe headaches or neurological symptoms Any signs of contaminated product (unusual smell, cloudiness) Unexplained fatigue or cognitive impairment Skin reactions or immune system hypersensitivity

Side Effects

When to Stop

Start with lowest effective dose (250mcg) to assess individual response

Selank has excellent safety profile with minimal reported side effects
No known tolerance, dependence, or withdrawal issues reported
Can be safely combined with most medications under medical supervision
Store properly refrigerated to maintain peptide stability and potency
Use sterile injection techniques to prevent infection
Consult healthcare provider if taking multiple psychiatric medications

Severe allergic reactions (rash, difficulty breathing, swelling)
Persistent injection site reactions or signs of infection
Unusual mood changes or increased anxiety (rare)
Severe headaches or neurological symptoms
Any signs of contaminated product (unusual smell, cloudiness)
Unexplained fatigue or cognitive impairment
Skin reactions or immune system hypersensitivity

Mechanism of Action & Molecular Information

Allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, BDNF upregulation in hippocampus

Weight	Length	Type
751.89 Da	7 amino acids	Tuftsin analog
Amino Acid Sequence:
Thr-Lys-Pro-Arg-Pro-Gly-Pro

References

Research Studies
GABAergic Neurotransmission Gene Expression (2016) `Rat frontal cortex \| 300 μg/kg \| Real-time PCR analysis` Demonstrated Selank's modulation of 45 genes involved in neurotransmission, confirming GABAergic mechanism similar to benzodiazepines without negative effects
BDNF Expression Enhancement Study (2010) `Rat hippocampus \| 250-500 μg/kg \| 24-hour measurement` Found 30% increase in hippocampal BDNF levels, indicating enhanced neuroplasticity and neuroprotective effects
Generalized Anxiety Disorder Clinical Trial (2008) `Human subjects \| GAD and neurasthenia \| Multi-week treatment` Showed significant anxiolytic and mild nootropic effects lasting up to one week after last dose, improved quality of life without dependence
Memory Consolidation Enhancement (2007) `Rat models \| Learning paradigms \| Head-to-head with Piracetam` Demonstrated significant activation of learning processes in subjects with initially poor learning ability, effects apparent after first administration

Research Studies

GABAergic Neurotransmission Gene Expression (2016)

Rat frontal cortex | 300 μg/kg | Real-time PCR analysis

Demonstrated Selank's modulation of 45 genes involved in neurotransmission, confirming GABAergic mechanism similar to benzodiazepines without negative effects

BDNF Expression Enhancement Study (2010)

Rat hippocampus | 250-500 μg/kg | 24-hour measurement

Found 30% increase in hippocampal BDNF levels, indicating enhanced neuroplasticity and neuroprotective effects

Generalized Anxiety Disorder Clinical Trial (2008)

Human subjects | GAD and neurasthenia | Multi-week treatment

Showed significant anxiolytic and mild nootropic effects lasting up to one week after last dose, improved quality of life without dependence

Memory Consolidation Enhancement (2007)

Rat models | Learning paradigms | Head-to-head with Piracetam

Demonstrated significant activation of learning processes in subjects with initially poor learning ability, effects apparent after first administration

Important Note
This content is intended for educational purposes only and is not medical advice, diagnosis, or treatment.

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