EPITALON
The Life-Clock Reset | Synthetic Pineal Tetrapeptide - Telomerase Activator & Anti-Aging
What is Epitalon?
Epitalon (Epithalon, AEDG) is a synthetic tetrapeptide consisting of four amino acids (Ala-Glu-Asp-Gly) based on a naturally occurring pineal gland peptide. Developed by Russian scientist Vladimir Khavinson and studied for over 35 years, Epitalon is primarily researched for its ability to activate telomerase, extend telomeres, and potentially slow cellular aging through multiple mechanisms including melatonin regulation and gene expression modulation.
IMPORTANT: Current Western dosing protocols may be 50-100x higher than necessary due to translation errors from Russian literature.
Think of Epitalon as a "biological repair kit" for your cells that helps slow down the natural wear and tear of aging. It works by activating an enzyme that protects and lengthens the protective caps on your DNA, allowing your cells to stay healthy and divide for a longer period. Additionally, it helps reset your internal clock by boosting melatonin, which can lead to better sleep and improved immune function.
Key Benefits
Telomerase activation for telomere extension, enhanced melatonin production, improved immune function, potential lifespan extension, and systemic anti-aging effects through cellular rejuvenation.
Telomere Elongation: Studies indicate that Epitalon can trigger the production of telomerase, potentially reversing the shortening of telomeres that occurs during aging.
Melatonin Regulation: Epitalon has been shown to normalize the secretion of melatonin, helping to regulate circadian rhythms and improve sleep patterns in aging individuals.
Antioxidant Properties: It may decrease lipid peroxidation and increase the activity of antioxidant enzymes like superoxide dismutase (SOD).
Oncostatic Effects: Some animal studies suggest it may inhibit the development of spontaneous tumors and slow down the aging of the reproductive system.
Immune Support: It is believed to improve immune function by acting on the thymus gland.
Quick Start Guide
Typical Dose
200-500mcg per injection (Evidence-based protocol)
100mcg for a conservative start
How Often
Once daily for 10-20 days
Where to Inject
Subcutaneous: abdomen, thigh, or upper arm
Injection Timing
Morning injection preferred to align with natural circadian rhythms
Effects Timeline
Sleep: 3-7 days, Energy: 1-2 weeks, Cellular markers: 1-3 months
Storage
Refrigerate at 2-8°C, use within 30 days of reconstitution
Cycle Length
10-20 days per cycle
Break Between
4-6 months between cycles
Research Indications
🟢 Anti Aging - Most Effective
Telomere Extension
Activates telomerase to lengthen telomeres and extend cellular replicative lifespan at microgram doses
Cellular Rejuvenation
Reverses markers of cellular aging and improves mitochondrial function through low-dose signaling
Lifespan Extension
Animal studies show 25-33% lifespan increase using 30-40 μg/kg doses, not milligram doses
🔵 Neuroprotection - Effective
Pineal Function Restoration
Enhances pineal gland activity and normalizes age-related melatonin decline with microgram dosing
Neurogenesis Support
Upregulates neurogenic differentiation genes at nanogram concentrations, supporting brain plasticity
Retinal Protection
Clinical evidence shows 90% response rate using only 5μg per eye for age-related macular degeneration
⚪️ Immunity - Moderate
Thymus Regeneration
Restores thymus structure and function at low doses, improving T-cell production
Immune Surveillance
Enhances immune system ability to detect and eliminate abnormal cells through regulatory signaling
Reduced Immunosenescence
Counters age-related decline in immune function using physiological doses
What to expect
Day 1-3: Usually no immediate effects, some report subtle energy improvement
Day 3-7: Better sleep quality, more vivid dreams (melatonin effect)
Week 2: Enhanced morning energy, improved mood stability
Week 3-4: Skin quality improvements, better wound healing
Month 2-3: Laboratory markers may show telomere length changes
Long-term: Cumulative anti-aging effects with repeated cycles
NOTE: Effects should be similar to high-dose protocols due to biological saturation
Side Effects & Safety
Side Effects | When to Stop |
|---|---|
Generally well-tolerated with minimal side effects in studies
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Mechanism of Action & Molecular Information
Activates telomerase enzyme at extremely low concentrations (10⁻¹⁷ to 10⁻¹⁵ M) to maintain telomere length, stimulates pineal gland for melatonin production, modulates gene expression through epigenetic mechanisms, and enhances antioxidant enzyme systems.
Weight | Length | Type |
|---|---|---|
390.35 Da | 4 amino acids | Tetrapeptide |
Amino Acid Sequence: | ||
Ala-Glu-Asp-Gly | ||
References
Research Studies | Citations |
|---|---|
Neurogenesis Gene Expression Study (2020)
Epitalon upregulated neurogenic differentiation markers (Nestin, GAP43, β-Tubulin III) by 1.6-1.8 fold in human gingival mesenchymal stem cells at extremely low concentrations, suggesting epigenetic regulation of neurogenesis. | Khavinson, V.Kh., Bondarev, I.E., Butyugov, A.A. (2003). Peptide correction of age-related pineal disturbances in monkeys. Bulletin of Experimental Biology and Medicine, 135(1), 18-21.
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Retinal Degeneration Trial (2019)
Patients with age-related macular degeneration showed improved visual acuity and slowed disease progression using only 5 micrograms per eye daily, suggesting neuroprotective effects at very low doses. | Anisimov, V.N., Khavinson, V.Kh., Morozov, V.G. (2003). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology, 4(4), 193-202.
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Telomerase Activation in Human Fibroblasts (2003)
Landmark study showed Epitalon activated telomerase in telomerase-negative human fibroblasts, extending their replicative lifespan from 34 to 44+ passages while maintaining telomere length comparable to young cells. | Labunets, I.F., Khavinson, V.Kh., Stepanyuk, G.I. (2002). Geroprotective effect of thymalin and epithalamin. Bulletin of Experimental Biology and Medicine, 134(5), 451-453.
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Lifespan Extension in Mice (2003)
Aging mice treated with extremely low doses of Epitalon (approximately 30-40 μg/kg) showed significant lifespan extension and reduced chromosomal aberrations, demonstrating efficacy at microgram doses. | Kossoy, G., Anisimov, V.N., Ben-Hur, H., Kossoy, N. (2006). Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo, 20(2), 253-257. |
Pineal Function with Low-Dose Epitalon (2001)
Elderly patients showed restoration of circadian melatonin rhythm, improved sleep quality, enhanced emotional stability, and increased physical stamina after low-dose synthetic Epitalon treatment. This study used microgram, not milligram doses. | Ashapkin, V.V., Kutueva, L.I., Kurchashova, S.Y. (2025). Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences, 26(6), 2691.
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Russian Clinical Trials with Epithalamin Extract (1992-2007)
IMPORTANT NOTE: This study used epithalamin (natural extract), not synthetic epitalon. Long-term clinical observations by Khavinson team showed significantly lower all-cause mortality in elderly subjects receiving periodic epithalamin courses compared to controls, with improved cardiovascular and immune parameters. | Varga, J.L., Matkovics, A., Dévai, G. (2008). Biomedical journals and databases in Russia and Russian language translation issues. Journal of the Medical Library Association, 96(4), 348-355.
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Important Note
This content is intended for educational purposes only and is not medical advice, diagnosis, or treatment.
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